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Sagging skin · Loose jawline · Volume loss · Structural descent
5 treatments
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Early laxity · Crepey skin · Texture · Jawline firmness
2 treatments
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Melasma · Dark spots · Sun spots · Uneven skin tone
1 treatment
Eye Bags & Dark Circles
Eye bags · Dark circles · Tear troughs · Puffy eyes
3 treatments
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Hair loss · Thinning hair · Receding hairline · Scalp health
2 treatments
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Square jaw · Double chin · Undefined jawline · V-shape face
3 treatments
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Stubborn fat · Muscle definition · Body shaping · Targeted fat reduction
2 treatments
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Polynucleotide skin booster treatment at Vincere Aesthetics Clinic, Singapore
Skin Boosters & Glow

Polynucleotide Skin Treatment

Regenerative skin quality therapy

Polynucleotide skin treatment uses short fragments of purified DNA — injected into the skin to support cellular repair, dermal regeneration, and gradual skin quality improvement. Administered by Dr. Vincent.

Duration
30–45 min
Downtime
Minimal
Results
4–8 weeks
Longevity
6+ months
About the Treatment

About polynucleotide skin treatment

Polynucleotides are short fragments of purified DNA that, when injected into the skin, support the natural processes of tissue regeneration. They stimulate fibroblasts (the cells responsible for collagen production), improve local micro-circulation, and create a more supportive environment for healthy skin cell turnover. Where skin boosters primarily address hydration, polynucleotides act on a deeper, regenerative level — improving the underlying biology of the skin itself.

The treatment is suited to clients whose primary concern is skin quality rather than volume or shape: thinning dermal tissue, loss of resilience, dullness that hydration alone doesn't fully address, or skin that has been stressed by sun exposure, lifestyle, or previous treatments. Polynucleotides work gradually, with effects building over a series of sessions as the dermis responds.

At Vincere, polynucleotide therapy is positioned as a regenerative tool — distinct from skin boosters (hydration), bio-remodelling (collagen and elastin stimulation through stabilised hyaluronic acid), and structural fillers. Dr. Vincent will help you understand which approach — or which combination — best matches your skin's needs.

Duration
30–45 min
Downtime
Small bumps at injection sites settle within 24–48 hours
Results
Quality improvement progresses across a series of sessions
Longevity
Cumulative effect with maintenance
Is This for Me?

Common concerns addressed

Thinning, fragile skin

Skin that has lost dermal volume and resilience — often visible as crepiness, fragility, or skin that bruises more easily than it once did.

Sun-damaged or environmentally stressed skin

Years of cumulative sun exposure or environmental stress that have affected skin quality at the cellular level. Regenerative support helps rebuild a healthier dermal foundation.

Skin quality after weight loss or major life changes

When skin needs help recovering from significant change — supporting tissue regeneration during a period of structural adaptation.

Periorbital and delicate-area skin quality

The area around the eyes and other delicate zones where standard treatments are too aggressive but skin quality has declined.

Maintenance after past aesthetic work

For clients who have had previous lifting or volumising treatments and want to support skin quality alongside their structural results.

Comprehensive skin quality protocols

Used alongside skin boosters or other treatments for clients wanting both hydration and regenerative support.

Your Journey

Your treatment journey

01

Skin assessment

20 min
Dr. Vincent examines your skin quality, dermal condition, and goals. Whether polynucleotide alone or in combination with other regenerative treatments will produce the most meaningful change is discussed.
02

Skin preparation

20–30 min
Topical numbing is applied and given 20–30 minutes to take effect. The treatment area is cleansed and marked according to the planned injection pattern.
03

Polynucleotide injection

15–25 min
Small volumes of polynucleotide solution are placed in a distributed pattern across the treatment area using a fine needle or micro-cannula technique. The pattern ensures even regenerative stimulation.
04

Aftercare & series planning

10 min
Small bumps or mild swelling at injection points typically settle within 24 to 48 hours. A series of 3 sessions spaced 3 to 4 weeks apart is the typical starting protocol; effects build progressively across the series.
Why Vincere

Why choose Vincere

Skin quality work is one of the most subtle areas of aesthetic medicine — the changes are gradual, and the patient and clinician must share an understanding of what good progress looks like. Dr. Vincent approaches polynucleotide therapy as part of a broader skin quality conversation: what is the underlying issue, which tools address it, and what realistic timeline applies?

The technique itself requires the same precision as any injectable — even distribution, correct depth, careful placement. As an AMI Faculty trainer, Dr. Vincent brings consistency to the placement that matters for cumulative regenerative effect.

Polynucleotide is not a quick fix. Most clients see meaningful change after the second or third session, with cumulative improvement across a series. The clinic's positioning is honest about this: gradual, layered improvement is the goal, not single-session transformation. Patience is rewarded; rushing the protocol is not.

Thousands
Injectable procedures performed
AMI
Faculty trainer & mentor
3 sessions
Typical starting protocol
Doctor
Personally treats every client
FAQ

Frequently asked
questions

Can't find your answer here? Message Dr. Vincent — he's happy to address your concerns personally.

Skin boosters primarily hydrate by adding hyaluronic acid to the dermis — addressing skin moisture and plumpness. Polynucleotides act regeneratively at the cellular level — stimulating fibroblasts, supporting micro-circulation, and improving the underlying dermal environment. They serve different purposes and are often used together: skin boosters for hydration, polynucleotides for regenerative quality improvement.
Polynucleotide skin treatment typically starts with a series of 3 sessions spaced 3 to 4 weeks apart. Most clients see meaningful change after the second or third session; some continue to a longer protocol depending on response and starting condition. Maintenance sessions every 6 to 12 months help preserve the regenerative effect.
Polynucleotide skin treatment works gradually. Most clients begin to notice subtle skin quality improvements 4 to 6 weeks after the second session — better resilience, improved texture, a healthier overall appearance. The cumulative effect across the series is what produces meaningful change.
The polynucleotide products used in aesthetic medicine are highly purified DNA fragments derived from controlled sources, with established safety profiles. Side effects are generally limited to mild bumps or swelling at injection points. Dr. Vincent will review your medical history at consultation and explain any specific considerations for your case.
Polynucleotide skin treatment is well-tolerated. Topical numbing is applied before injection. The sensation is described as small pinches at each injection point. The micro-cannula technique used in some areas reduces sensation further.
Polynucleotide downtime is minimal. Small bumps or mild swelling at injection points are common and typically settle within 24 to 48 hours. Some clients experience minor bruising that resolves in a few days. Most return to normal activities the same day; some prefer scheduling on a Friday if they want the bumps to settle before social plans.
Yes — polynucleotides are often used as part of a broader skin quality protocol. They complement skin boosters (different mechanism, complementary effect), support recovery after laser or microneedling treatments, and add regenerative support alongside structural fillers. Dr. Vincent will discuss how polynucleotides fit into your overall plan at consultation.
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